Endocrine Abstracts

BackgroundThe multiple endocrine neoplasia syndrome type 2 (MEN-2) is characterized by medullary thyroid cancer (MTC) as a permanent feature; the combination with pheochromocytoma and parathyroidism is referred as MEN-2a syndrome. The reason for hereditary forms of MTC is mutations in the proto-oncogene RET (RE-arranged during Transfection).The aim of the study was to establish the molecular determinants frequency of MEN-2 syndrome...

BackgroundMedullary thyroid cancer (MTC) is a calcitonin-producing C-cell tumor and accounts about 5% in the structure of thyroid malignancies. There are sporadic and hereditary variant of MTC, which is a mandatory component of endocrine neoplasia syndrome type 2. The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and demographic characteristics.Materials and methods<...

BackgroundThe management of patients with medullary thyroid cancer (MTC) has an important endocrinological aspect, because MTC can be a manifestation of multiple endocrine neoplasia syndrome (MEN), a genetically determined pathology with an autosomal dominant inheritance. MEN-2 syndrome is characterized by of MTC as a permanent feature, the combination with pheochromocytoma and/or adenoma of the parathyroid glands. The aim of the study was to determine t...

Background: The treatment of neuroendocrine neoplasms (NENs) of higher grade remains a dilemma. In these patients the role of immunotherapy is still unclear and predictive biomarkers are an unmet need. Herein, we present a revised translational analysis of the NET001 and NET002 (NCT03278405, NCT03278379) clinical trials.Methods: Patients with advanced WHO G2-3 NENs who had a gastroenteropancreatic (GEP) or a bronchial primary (excluding typical carcinoid...

Recent years have demonstrated increasing focus on augmenting secretion of glucagon-like peptide (GLP)-1 from intestinal L cells, to improve the treatment and/or prevention of obesity and type 2 diabetes. However, finding strong stimuli and identifying novel compounds has proven difficult. To discover new GLP-1 secretagogues, we gave 49 individuals (76% female, BMI 28.3±4.8 kg/m2) a high-fat liquid mixed meal (250 mL Nutridrink, Nutricia®). Plasma samples,...

Hepatocellular carcinoma (HCC) is an aggressive tumour frequently associated to an underlying chronic liver disease. In this sense, metabolic dysfunction-associated steatotic liver disease (MASLD) is considered as a growing cause of HCC development. Considering the need of novel therapeutic approaches, and the promising data about targeting the tumour microenvironment in cancer, we performed quantitative proteomics on HCC samples to characterize the components and regulators o...

Adrenocortical Carcinoma (ACC) is a rare and lethal disease with a poor prognosis. This study aims to share our 41-year experience as a referral center, focusing on identifying risk factors associated with ACC mortality. Our retrospective analysis included a cohort of 150 adult patients with ACC in all stage categories, treated between 1981 and 2022. Tumor hormonal hypersecretion was observed in 78.6% of the patients, and the median age of diagnosis was 40 years. The majority ...

Introduction: Nutritional status in patients with neuroendocrine tumors (NETs), especially with gastroenteropancreatic origin, may be affected and have an impact on prognosis and survival. Different techniques are currently available to assess nutritional status, but not all of them are accessible in routine clinical practice. In this context, Body composition of NET patients was calculated by computed tomography (CT) at L3 level to evaluate its importance on clinical prognosi...

Objective: Glucocorticoid-induced adrenal insufficiency is highly prevalent, but the clinical consequences are not fully understood. Therefore, the indication of adding stress dosages of glucocorticoid during ongoing anti-inflammatory glucocorticoid treatment remains unclear. The aim of this study was to determine the impact of adrenal function on health-related quality of life (HRQoL) in patients receiving ongoing low-dose prednisolone treatment.Methods...

Hormonal signalling plays a key role in the progression of metabolic (dysfunction)-associated fatty liver disease (MAFLD) to hepatocellular carcinoma (HCC). However, the role of somatostatin (SST), cortistatin (CORT), neuronostatin (NST) and ghrelin systems in MAFLD-HCC progression has not yet been elucidated. We characterized the role of SST/CORT/NST and ghrelin systems in chronic liver disease and evaluated their clinical potential. The expression of the components of the SS...